Tritium Radiolabelled Antisense Oligonucleotides for ADME Studies
نویسنده
چکیده
K. Webbley, S. Harris, J. Bloom, C. Henson, V. Wilson, C. Hawes, D. Price, J. Haffenden Pharmaron, Inc. Purpose Antisense Oligonucleotides (ASO), continue to elicit interest as novel therapeutic agents designed to specifically and selectively inhibit the production of various disease related gene products. For efficacy to occur, the therapeutic material must reach the site of action in quantities sufficient to produce the desired therapeutic effect. An understanding of the pharmacokinetics of ASOs and, in particular, the mechanisms by which oligonucleotides accumulate in tissues and in cells is therefore critical for the development of effective antisense therapeutics.
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